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9, show increases in mitochondrial mass and signalling

The zinc binds to specific residues in the peptide chain, and without it the molecule remains in an unfolded state

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Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use

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