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A number of health conditions are associated with low levels of intracellular glutathione including neurological deficits, cognitive issues, parkinsons disease, autism and respiratory conditions

263 In castration-resistant prostate cancer, the UPS supports androgen receptor (AR) function by facilitating its nuclear localization and stabilizing mutated AR proteins, enabling tumor cells to survive and proliferate under low androgen levels

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2011;6:e19456

doi: 10.1111/imcb.12040 75 BajwaGDeBerardinisRJShaoBHallBFarrarJDGillMA