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39 We determined that SMAD3 was generating the majority of the effects that we were seeing both in vivo and in vitro by showing that treatment with SIS3 was able to reverse the effects of TGF 1

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Key Takeaways BPC-157 is a synthetic 15-amino-acid peptide (molecular weight approximately 1419.5 Da) with no completed, published human RCTs as of mid-2026, making all clinical extrapolations low-to-very-low grade evidence

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