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Cuprizone-induced demyelination in animals is accepted for studying multiple sclerosis-related lesions and is characterized by degeneration of oligodendrocytes more than by a direct attack on the myelin sheet (12)

The oxidized form of glutathione (GSSG), which predominates in the ER lumen compared to the cytosol, was formerly thought to reoxidize protein disulfide isomerase (PDI) to promote ER disulfide bond formation

Excessive stressors that overwhelm cellular adaptation can trigger the activation of pathways leading to regulated cell death (apoptosis) [17]

We found that hemin increases S-Adenosyl methionine (SAM) levels but not S-Adenosyl-L-homocysteine (SAH)

Most cycles run for 24 weeks , though some extend up to 6 weeks based on severity of injury or recovery needs