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Furthermore, glutamine creates the main source of glutamate for the production of glutathione, which is essential in reducing oxidative stress, which eventually results in maintaining inflammatory processes within -cells in diabetes [12]
Notwithstanding, TIR alleviated memory impairment in STZ-induced diabetic rats by modulating insulin resistance and the inflammatory response through restoration of the PI3K/Akt/GSK-3 signaling pathway ( This study possesses distinct strengths and limitations

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In the colon, only a few macrophages were observed in the submucosal layer on the 3rd day after DSS treatment, but on the 5th day, many macrophages were observed in the mucosal and the submucosal layer where the colon plicae had collapsed (Fig