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Our study shows that in theory-based modeling, PK parameters were estimated based on C p ( CYP3A5*3*3 patients with an AST of 45 U L 1 , administered TAF-free treatment and 1 mg tacrolimus DD, estimated CL pl /F was 234 L h 1 , which is much lower than the reported value (473695 L h 1 ) for non-Asian liver transplant ( 1 ) ( versus liver transplants ( Both final models indicated that only the CYP3A5*3 genotype recipients significantly affected tacrolimus PK in liver transplant patients, consistent with published data ( CYP3A5*1*3 or CYP3A5*1*1 had 16.8% higher CL pl /F and 36.5% lower K m values than those of CYP3A5*3*3 carriers