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The RIPENING-INHIBITOR (RIN) transcription factor, a master regulator of fruit maturation, exerts direct control over lycopene accumulation by binding to the promoters of critical biosynthetic genes

They noticed that the effects weren't just local

ITF is a small peptide found abundantly throughout the gut and known to concentrate at sites of injury, such as in proximity to peptic ulcers [113]

Notably, IL-6 enhanced the cell index of 12Z cells relative to the untreated group, aligning with previous research linking elevated IL-6 levels to increased proliferation of endometriotic cells in the late stages of the disease 28

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