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Some mechanisms have been studied in rodent organotypic cultures

Jomova K, Valko M (2011) Thermodynamics of free radical reactions and the redox environment of a cell in oxidative stress: diagnostics, prevention, and therapy, ACS, pp 7182 Jrns A, Tiedge M, Lenzen S, Munday R (1999) Effect of superoxide dismutase, catalase, chelating agents, and free radical scavengers on the toxicity of alloxan to isolated pancreatic islets in vitro

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In the future, in-depth analysis of the molecular mechanisms by which it induces gut microbiota dysbiosis (such as LPS release, activation of inflammatory signaling pathways, etc.) may offer a significant theoretical basis to support the development of OA therapeutic

Chronic Kidney Disease Chronic Kidney Disease Last Section Update: 12/2025 Contributor(s) : Maureen Williams, ND