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It also identified that people who said that they used cannabis and tobacco together were more likely to report mental health problems than those who used either product on their own

They also found that PNE increased the expression of the D5 dopamine receptor in the striatum but did not influence exploratory locomotion, the delay-discounting test, or the expression of other dopamine-related genes ( DRD4 , DAT1 , NR4A2 , and TH ) in either the PFC or the striatum [80]

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