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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

Some individuals may experience mild injection-site reactions (e.g., redness, swelling) or occasional headaches

Nature 458 , 11311135 (2009)

Discussion Several drugs have been known to provoke acneiform eruptions or aggravate acne, including corticosteroids, anti-tubercular drugs, anticonvulsivants, antipsychotics, some anti-cancer agents, and others