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These metabolites, together with mitochondrial DNA released into the cytoplasm, activate the NLRP3 inflammasome and cGAS-STING pathways, driving the release of IL-1 and type I interferons

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In vitro, NKG2D CAR-T cells selectively eliminate senescent fibroblasts induced by different stresses as well as in vivo, in mice and non-human primate aged models where the effects of this cell therapy are significant without any toxicity observed

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