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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1

et al.Patritumab deruxtecan (HER3-DXd) in early-stage HR + /HER2 breast cancer: final results of the SOLTI TOT-HER3 window of opportunity trial