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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.De Caterina R., Libby P., Peng H.B., Thannickal V.J., Rajavashisth T.B., Gimbrone M.A., Jr., Shin W.S., Liao J.K

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To provide a more accurate prediction of skin irritancy potential of the test compound, in vitro skin irritation test can include other potential biomarkers

Importantly, FIH studies also provide essential information for the design of Phase 2 trials , including decisions related to dosing schedules, administration frequency and safety monitoring strategies

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