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enhancing their oral bioavailability by inhibiting intestinal P-glycoprotein Reference: Katzung's text & MedSciMonit, 2004

Semaglutide 2.4 mg not only promotes weight loss but also improves eating control, reduces food cravings, and reduces the usual appetite increase after significant weight loss, supporting ongoing weight management

The limited absorption of the nasal cavity restricts the amount of drug being effectively absorbed, making class I drugs (high permeability, high solubility), according to the Biopharmaceutics Drug Disposition Classification System (BDDCS), particularly suitable for nasal delivery (Ugwoke et al., 2001)