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Product References
MRTX1133 selectively inhibits KRAS G12D mutant
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MRTX1133 Pack Size:1 mg Product ReferencesMRTX1133 is a noncovalent, potent, and selective KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated KD against KRAS G12D of 0. 2 pM. MRTX1133 prevents SOS1 catalyzed nucleotide exchange and or formation of the KRAS G12D GTP RAF1 complex, thereby inhibiting mutant KRAS dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D
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