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June 2019

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Assessment of mucosal injury Immediately after euthanizing the rats, the tongue, esophagus, stomach, and duodenum were removed and the lesion areas, presenting as the redness, congestion, or frank ulcerations were assessed (mm2, mean SD) (30-33)

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The key effects are well-established: accelerated cell turnover (the outer layers of the stratum corneum, the skin's surface barrier, shed more quickly), direct stimulation of procollagen genes, and suppression of matrix metalloproteinases - the enzymes responsible for breaking down existing collagen