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Preclinical studies document significant brain concentrations after systemic (including oral) administration, with behavioral improvements in hippocampal-dependent tasks confirming functionally relevant CNS penetration (PMID: 23055539)

Tooth abscesses, cavities, impacted wisdom teeth, or gum infections can create referred pain that feels like it is coming from the ear

PMID: 30144361

References Leslie SW, Siref LE, Soon-Sutton TL, Khan MAB

POTENTIAL APPLICATIONS IN OTHER INFLAMMATORY CONDITIONS Studies suggest possible therapeutic roles influencing chronic respiratory conditions, joint inflammation, and other immune system disorders