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Carrying out the meta-analyses Fixed-effect and random-effects meta-analyses were conducted using the method of Fleiss and Gross [13], with heterogeneity quantified by H, the ratio of the heterogeneity chisquared to its degrees of freedom, which is directly related to the statistic I 2 [16] by the formula I 2 = 100 (H-1)/H

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however, studies are currently inconclusive