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For instance, the combination of Sulodexide and Jinshuibao has been shown to confer benefits in early diabetic nephropathy by simultaneously improving oxidative stress and inflammatory markers 11 , Glucagon-Like Peptide-1 (GLP-1) receptor agonists improve hepatic lipid metabolism through the AMP-activated protein kinase (AMPK)/Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) pathway 12,13,14 , Given the complex, multi-system nature of T2DM/MASLD, there is a clear unmet need for multi-target agents capable of blocking the metabolic-inflammatory-fibrotic cascade, which single-pathway interventions often fail to address

Among them, the glutathione system made up of GSH, enzymes involved in GSH anabolism, and GSH-dependent antioxidant enzymes play a critical role in cardioprotection from oxidative stress and redox homeostasis [12,13,14]

Pharmacological profile of progestins

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

These glutathione transferases also have antioxidant properties