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Immunohistochemical staining showed higher expression of p16 in keloids than that in normal skin ( p = 0.01

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Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)

Week 3-4 What to expect : Significant pain reduction (50-70%) Improved range of motion Better strength Functional improvements Visible progress Week 5-6 What to expect : Near-complete healing (70-90%) Return to activities Minimal discomfort Continued improvement Post-protocol (weeks 7-10) What to expect : Continued healing for 2-4 weeks after stopping Further improvements Stabilization Read complete BPC-157 benefits