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244 In addition, tumor cells can consume a large amount of Met in the environment by highly expressing Met transporter SLC43A2, which can inhibit the Met metabolism of T cells in the microenvironment, resulting in the loss of dimethylation of histone H3K79me2 lysine 79 in T cells, low expression of STAT5, and inhibition of T cell function

Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, et al: Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet

Downregulated metabolites included glutamine, isoleucine, and deamido-NAD + , whereas upregulated metabolites included acylcarnitines, succinyladenosine, and leukotriene B4

Following conjugation, GSH-conjugated metabolites are exported via multidrug resistance-associated proteins (MRPs) and processed through the mercapturic acid pathway for renal excretion

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