Clinical research in older humans confirms these mechanisms translate to human aging
The results described in PDAC cells have also been confirmed in human breast cancer after genetic or pharmacologic inhibition of this transporter (28)
Similarly, mutations in the ATP13A2 gene associated with PD result in widespread lysosomal impairment, characterized by membrane instability, impaired acidification, reduced processing of lysosomal enzymes, and diminished degradation of substrates and autophagosomes [118]
doi: 10.1089/jwh.2008.1255 298 Prez-TorresIManzano-PechLRubio-RuzMESotoMEGuarner-LansV
First characterised by Professor Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, BPC-157 has since become one of the most widely studied peptides in preclinical research, spanning gastrointestinal biology, musculoskeletal repair, neuroprotection, and cytoprotective signalling