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Many skin and anti-aging research protocols run continuously across the research timeline rather than using cycling patterns, because the gene expression effects are studied as sustained signals rather than acute pulses

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There were faster granulation tissue formation, re-epithelialization, dermal remodeling, and collagen deposition through extracellular signalregulated kinases (ERK)1/2 signaling pathway as well as its downstream targets, including c-Fos, c-Jun, and egr-1