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The accumulated Ca 2+ binds to the membrane, exposing specific buried thiols to the oxidants and impairing mitochondrial respiration, resulting in increased superoxide formation

2.3 Aberrant changes in mitochondrial structure and function during AKI 2.3.1 Mitochondrial dysfunction Mitochondrial dysfunction in AKI is characterized by impairments in mitochondrial biogenesis, attenuation of mitophagy, disrupted mitochondrial dynamics, and reduced OXPHO activity (Figure 1) (Emma et al., 2016)

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