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Research demonstrates TB-500 reduces inflammatory markers including IL-6 and TNF-alpha while releasing the anti-inflammatory fragment acetyl-SDKP, creating conditions that favor repair over chronic inflammation

The role of TNF and IL-6 as master regulators of tumor-associated inflammation and tumorigenesis makes them attractive targets for adjuvant treatment in cancer

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Another study in female C3H/He mice reported fewer malignant-tumour-bearing animals and no detected metastases in the treated group during the observation period

Critically, the peptide showed therapeutic efficacy even when administered after neurotoxin exposure