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These proteins are implicated in mitosis, fatty acid metabolism, p53-dependent apoptosis and complex I of the mitochondrial respiratory chain, respectively ( Supplementary Table S1 )
In the SURMOUNT-1 trial, participants lost up to 22.5% of body weight over 72 weeks (study on tirzepatide in obesity)
At the same time, inhibiting NNMT also helps preserve another important molecule: S-Adenosyl Methionine (SAM)
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