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The short answer is that glutathione is generally considered safe because it is a substance your body already produces and requires

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Apparently the factors that lower the enzymatic degradation and metabolism of a peptide tend to stabilize the peptide 48,49

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However, if you are exposed to more toxins than usual (say in the workplace), have ongoing levels of high stress, have an imbalanced immune system (weak or overactive such as autoimmune), have a chronic disease, or need to take medications, then you should consider supplementing glutathione