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While the procedure is generally straightforward and safe, it often raises questions about changes in the body afterward

Emerging multi-stakeholder consortia that include academia, industry, and regulators are beginning to shape this landscape by sharing data, defining best practices, and establishing reference materials for evaluation

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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67