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Studies have identified an imbalance in the composition of gut microbiota (too many bad bacteria compared with good) in rodents exhibiting depressive behavior (6)

doi: 10.1038/s41590-020-00829-6 57 ZhangWHuangHCaiHTanWS

18 Zhao et al attempted to modify EA using thiazole derivatives of uric acid to strengthen its GST-inhibitory effects

In addition, levels of Toll Like Receptor 4 (TLR4) and inflammatory factors, such as Nuclear Factor B (NF-B), IL-6 and Monocyte Chemoattractant Protein-1 (MCP-1), were also significantly decreased compared to the untreated PE group