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The binding of the RGD motifs to the V integrins expressed in tumor endothelial cells induces the protease-mediated cleavage of the iRGD peptide, producing two peptides, namely, CRGDR/K and GPDC

Kojima & Kangawa 2001 An interactive 3D model rendered from the compound record rotate and explore its structure

Pre-blending with flow agents (silicon dioxide, magnesium stearate)

It showed that APAP metabolites can induce neurotoxicity like oxidative stress, glutathione depletion, and endocrine disruption

Conventional gastroprotective drugs commonly prescribed to minimize NSAID toxicity or heal NSAID-induced ulcers include H2-receptor antagonists (cimetidine, ranitidine, famotidine), proton pump inhibitors (omeprazole, lansoprazole, esomeprazole), and misoprostol (a synthetic prostaglandin analog) (Vonkeman 2010)