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In vitro studies are preferrable but rely on having a biorelevant system that can representatively simulate the physiological conditions associated with this specific drug delivery process

Front Endocrinol (Lausanne) 14:1070592

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

however, most results were obtained via single-center observational and retrospective studies and lack information on confounding factors, such as duration of PPI exposure, antibiotic intake, and dietary patterns

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