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Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)

Although most of the FRET applications in the early days were related to the estimation of distances between interacting partners, in 1978, Elisa Haas, Ephraim Katchalski-Katzir, and Izchak Z

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