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Reactive astrocytes, in response to oxidative stress, alter the expression of key enzymes such as nitric oxide synthase (NOS), NADPH oxidase (NOX) enzymes and fatty acid amide hydrolase, which, in turn, enhance the production of oxidative agents 93

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Each of the functional IDH3 enzymes is a heterotetramer composed of three different subunits identified as the , , and subunits