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These agents can be classified into several categories based on their mechanisms of action and chemical structures, including inhibitors of sterol synthesis, cell wall synthesis, DNA synthesis, and cell membrane function

For instance, a study demonstrated that blocking MCU significantly reduced ROS production and mitochondrial swelling in iron-overloaded thalassemic mice, suggesting that MCU could be a therapeutic target for preventing mitochondrial dysfunction in IOC (41, 89)

Furthermore, it seems to have a powerful modulatory effect on nitric oxide (NO) pathways and can protect endothelial tissue, the thin layer of cells lining blood vessels

KPV is a synthetic analogue of alpha-melanocyte stimulating hormone

Understanding these mechanisms provides key insights into the pathology of cadmium-induced hepatotoxicity (158)