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Hepatocytes could also dedifferentiate into hepatic progenitor cells (HPCs, which are identified by markers such as SMA, SOX9, KRT19, EpCAM, and PROM1), and the proliferation and differentiation of hepatocyte-derived HPCs are closely associated with ductular reactions and portal fibrosis in liver injury (101)

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Hence, to ensure proper functionality, ApoE necessitates both secretion and lipidation (Figure 2) (Minagawa et al., 2009

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