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As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy

Issa GC , Ambinder AJ, Xiao W, Manalis S, Shalek AK, Gondek LP, Kentsis A, Short NJ, Daver N, Ning J, Xiao L, Hemann M, Chen K, Patel KP, Bachireddy P, Lane AA, Konopleva M, Abdel-Wahab O, Molldrem JJ, Levine RL, Levis MJ, Stone RM, Andreeff M , Ravandi F, Goldberg AD, Garcia JS

[32] Weiduschat, N., Mao, X., Hupf, J., Armstrong, N., Kang, G., Lange, D.J