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We know that long-duration proton pump inhibitor (PPI) use is often associated with lower magnesium levels and deficiency. Meacham says

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Numerous studies have validated that the paracellular permeability ratio is greater in patients with Crohns disease and some of their clinically normal relatives [35, 36] and in patients with celiac disease [37] as compared with people unaffected by or unrelated to these disease states

Preclinical and early human research suggests its role in promoting longevity, regulating circadian rhythms, and supporting cellular repair processes, making it of great interest to researchers in gerontology, oncology, and molecular biology

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