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Fatigue can have many causes, including stress, poor sleep, hormone issues, nutritional deficiencies, or other medical concerns

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Patients with Chronic Pulmonary Disease: Hydrocodone bitartrate and acetaminophen tablet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of hydrocodone bitartrate and acetaminophen tablets (see WARNINGS, Life-Threatening Respiratory Depression)

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The thyroid gland is an endocrine gland that releases its hormones directly into the bloodstream and not through a duct