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first reported the dedifferentiation of hepatocytes into fibroblasts via EMT ( Snail and Slug , repressing the mesenchymal program and EMT of hepatocytes ( Hepatocytes could also dedifferentiate into hepatic progenitor cells (HPCs, which are identified by markers such as SMA, SOX9, KRT19, EpCAM, and PROM1), and the proliferation and differentiation of hepatocyte-derived HPCs are closely associated with ductular reactions and portal fibrosis in liver injury ( Mat1a - / - mice transformed into fibroblastic cells when incubated with FGF10 and TGF-1, and these HPC-derived fibroblasts were significantly expanded in RRV-induced BA mouse model ( 9

Carrier free O 2 -economizer for photodynamic therapy against hypoxic tumor by inhibiting cell respiration

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These nutrients are known as cell-nutrients or precursors

249 Their similarity lied in the fact that lactate and acetyl-CoA both were primarily derived from the glycolytic end product, pyruvate and had similar molecular structures