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A decrease in phosphorylation of AKT, as regulated by PPAR 26 is associated with reduced mTOR activity 27

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Headache: Occasional, attributed to vascular adjustments

Some usage-limiting properties of the designed peptides, including low selectivity and tumor cell uptake, poor tumor permeability and passing through the BBB in glioma cancer, and low plasma stability, can be improved by several techniques, such as intracellular delivery via the intracellular pathway, ligand-mediated tumor targeting, and nanoparticle-based drug delivery systems