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JAMA, 330 (18), 1795-1797

LeachNVDroncaEVesaSCSampeleanDPCraciunECLupsorMet al

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Given the progressive nature of Put-GABA down-regulation in DA/GABA striatal neurons with chronic ethanol consumption, as well as potential diversion of these nitrogen substrates toward NO synthesis (Figure 1), it could be worthwhile to examine whether promoting polyamine synthesis in striatal DA/GABA neurons impacts ethanol withdrawal symptoms