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The increase in HMGB1 associated with liver damage may serve as an important biological marker to evaluate the severity and prognosis of the disease [227]

For example, patients with mild detoxification needs may start with lower doses administered over longer periods, while those with higher levels of heavy metal exposure might require more intensive protocols

Animal studies show significant acceleration in wound healing

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Beyond doses of 200500 mg, absorption efficiency falls sharply, and higher oral doses commonly cause gastrointestinal discomfort, a particular concern for elderly patients