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revealed that a high level of glucose-mediated accumulation of ROS leads to auxin degradation through its oxidation, which adversely affects the root meristematic activity and eventually inhibits root growth via the conserved autophagic path [58]

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As deduced from an X-ray crystallographic analysis of 43 in complex with ERAP2 it was concluded that the three first specificity pockets of the enzyme was of particular importance for binding to the enzyme (Zervoudi et al., 2013)

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