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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+

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doi: 10.1159/000341934

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Around 60% reached a consensus that it could be a useful adjuvant in acute bacterial and viral infections and 60% agreed that it has a role in CAP but not in VAP