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Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

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Moreover, the structural and transcriptional abnormalities in the tumor endothelium facilitate the extravasation of cancer cells and promote metastasis development (30)

In parallel, zinc rapidly induces the expression and activation of lysosomal proteases cathepsin B and D, through early V-ATPase-dependent acidification and later TFEB-mediated transcription