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doi: 10.1016/j.biopsych.2018.08.018 138 RohlederN

This chelation is critical: it effectively silences the metals free redox activity, preventing oxidative damage from unbound copper ions while maintaining bioavailability

Directly supplementing with glutathione might be a more appealing option

To enhance the robustness and specificity of signal detection, only adverse events simultaneously meeting the positivity criteria of all four methods were considered true safety signals