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Drugs Affecting Blood and Blood Formation

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Morphologically, ferroptosis is characterized by necrotic-like features, including loss of mitochondrial cristae, increased membrane density, outer membrane rupture, and reduced mitochondrial volume, while preserving plasma membrane integrity during early stages and maintaining normal nuclear morphology

The key feature of ferroptosis is the accumulation of lipid hydroperoxide, resulting from a decrease in glutathione peroxidases (GPXs)

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