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Oral administration at 100150mg to match subcutaneous bioavailability doubles the per-dose cost, which influences protocol design when budget constraints exist

As GSH represent the primary antioxidant defense system, the reduction of GSH could influence the redox homeostasis and elevate the naturally occurring ROS levels inside the cancer cells 40

These precautions preserve peptide integrity

This minimizes blockage of the nasal membrane and also optimizes absorption

Every escalation decision is reviewed by an independent Safety Review Committee, which evaluates all available data against predefined stopping rules