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This is likely due to an increase in reactive oxygen radicals or oxidative stress in the body

The PLP form of the enzyme can then catalyze another round of the -lyase reaction (Cooper, 1998, Stevens et al., 1986)

Nrf2 is a transcription factor that regulates several enzymes involved in cellular stress responses, some of which include superoxide dismutase catalase, glutathione peroxidase, and glutathione reductase 5