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In addition to its role in energy metabolism with some antioxidant properties, L-acetyl-carnitine can cross the blood-brain barrier, where it modulates brain neurotransmitters, such as acetylcholine, serotonin and dopamine, and acts on neurotrophic factors by modifying the activity of the relevant genes

doi:10.1016/j.xkme.2019.12.006 Watanabe H, Obata H, Watanabe T, Sasaki S, Nagai K, Aizawa Y

Longen, S

Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

10.1111/j.1471-4159.2007.04837.x 33 FarooqueU.OkorieN.KatariaS.ShahS